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Re: [PATCH] gnu: Add eigensoft.


From: Ricardo Wurmus
Subject: Re: [PATCH] gnu: Add eigensoft.
Date: Wed, 13 Jul 2016 08:38:15 +0200
User-agent: mu4e 0.9.16; emacs 24.5.1

Ricardo Wurmus <address@hidden> writes:

> * gnu/packages/bioinformatics.scm (eigensoft): New variable.
[…]
> +      (description "This package provides tools for population genetics and
> +stratification correction.  The EIGENSTRAT method uses principal components
> +analysis to explicitly model ancestry differences between cases and controls
> +along continuous axes of variation; the resulting correction is specific to a
> +candidate marker’s variation in frequency across ancestral populations,
> +minimizing spurious associations while maximizing power to detect true
> +associations.  The EIGENSOFT package has a built-in plotting script and
> +supports multiple file formats and quantitative phenotypes.")

Here’s an alternative description, which is a little more general and
doesn’t emphasise EIGENSTRAT so much:

  The EIGENSOFT package provides tools for population genetics and
  stratification correction.  EIGENSOFT implements methods commonly used
  in population genetics analyses such as PCA, computation of
  Tracy-Widom statistics, and finding relateds in structured
  populations.  It comes with a built-in plotting script and supports
  multiple file formats and quantitative phenotypes.

WDYT?

~~ Ricardo



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