[Top][All Lists]
[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
[Gnumed-devel] Re: Drugs interactions calculation
From: |
Jim Busser |
Subject: |
[Gnumed-devel] Re: Drugs interactions calculation |
Date: |
Mon, 12 Jul 2010 17:22:20 -0700 |
On 2010-07-12, at 3:20 PM, Eric MAEKER wrote:
> If you try, for ex, a really risky prescription like (please don't prescribe
> this to a real patient):
> FUROSEMIDE
> RAMIPRIL
> KETOPROFENE
> DIGOXINE
> KCl
> (Patient CrCl about 45 ml/min)
remove furosemide (because it might cause potassium loss)
add one or more of
beta-blocker
triamterene
spironolactone
> I can't find an easy solution... Anyone ?
Are the interactions "other" than "increased effect", "decreased effect" ? In
the example that you gave, it is only the KCl that has the "intended effect" of
altering (increasing) potassium... so, all of the other drugs could
"potentiate" the KCl "effect".
At a simplistic level, *four* drugs that potentiate (or weaken) a drug effect,
all in the same direction, are even more important to know about than a single
drug, so one could argue some "simple summation" enhanced warning. There might
be value to visual feedback that is directional... drugs that weaken an effect
on the left side, drugs that potentiate on the right side, of a detail table,
Such an approach would not take into account the strength of effects...
Supposing each effect *could* pre-scored on its strength of effect
mild
moderate
strong
one could argue for an additive or multiplier effect, but {mild, moderate,
strong} can be difficult to define, and non-linear.
*but* if the KCl was not in the prescription, you would never know, and
everything above would fall apart. It "hinges" on whether interactions will
include an interaction on the side effects of medications.
... I *suppose* if the side effects could be keyed as clinical conditions
(diseases), then the drugs could interact with the "disease" that is the side
effect that would be potentiated or weakened!
-- Jim
- [Gnumed-devel] Re: Drugs interactions calculation,
Jim Busser <=